#62 - Interaction of exercise with muscle circadian clocks with Dr Karyn Esser
Inside Exercise
Regulation and Function of Muscle Clocks
This chapter delves into the regulation of peripheral muscle clocks and their role in daily gene expression patterns. It also highlights the importance of muscle maintenance and repair during rest.
Dr Glenn McConell chats with Professor Karyn Esser from the University of Florida, USA. She is an authority on circadian biology. We discuss whether exercise affects muscle circadian clocks and whether muscle clocks affect exercise. What is the best time to exercise and to eat etc. Also the effects of jet lag and shift work and how to best manage these. A very interesting chat. Karyn’s Twitter: @kaesser.
0:00. Introduction
2:30. How Karyn got into exercise research.
4:40. She was “picked up” by Arnold Schwarzenegger
5:32. Her muscle hypertrophy work
7:00. What are circadian rhythms?
9:40. Jet lag
11:10. How central clocks and peripheral clocks interact
14:16. Social jet lag
15:45. Timing of running rodents because nocturnal
16:47. Best to wear sunglasses when jet lagged?
17:54. Melatonin
19:40. Muscle clocks prepare the muscle
26:54. Sleep onset and dark onset are not necessarily correlated
30:23. Time of day and exercise performance
34:10. Running in the morning can shift muscle clocks forward
37:00. Train at the time of the race
39:25. Contracting muscle cells and circadian rhythms
41:00. Timing of eating and muscle circadian rhythms
43:00. How long does it take to shift clocks/jet jag
45:10. Exercise: morning people vs evening people
47:58. Stronger in the afternoon
50:30. Shift work and eating during the night
54:30. Best to do rotating or constant routine shift work?
55:57. Best time to exercise if shift worker?
57:55. Clocks are disrupted in diabetes
1:00:00. Researchers need to consider circadian rhythms
1:03:42. Is there circadian rhythm cross talk between organs?
1:06:03. Inflammation, muscle and circadian rhythms
1:08:12. The heart and circadian rhythms
1:11:30. Bone-muscle cross talk and circadian rhythms
1:13:28. Sex differences and circadian rhythms
1:15:00. Applicability of mouse studies to humans
1:16:42. Controversies in the field
1:17:52. Takeaway messages
1:20:12. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
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Email: glenn.mcconell@gmail.com
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