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The Hippocampus in Attention and Perception Tasks
We wanted to understand the mechanisms by which that happened, so what are the neuromodulatory systems that might allow the hippocampus to contribute to performance in perception tasks. And we were very motivated by computational modeling studies and work with rodent models showing that the hippocampus might switch between states that are optimized for attending to the external world and states that areoptimized for retrieving memories. So these kind of switches between internal and external modes. If that's true, then if you manipulate the colonnergic system, you might be able to get people to perform better on attention and perception tasks that are recruiting the hippocampus.