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Cortisol or Glucocorticoids as an Anti-Inflammatory?
Cortisol or glucocorticoids as an anti-inflammatory, let me see if I have this right. When a cell fails at respiration, it can start producing cytokines and those leak out to the blood. And then the response to that is obviously one of the hormones increasing cortisol. But when you're increasing endotoxin permeability, because that's what cortisol does, they compromise the gut barrier. So your anti-cytokine effects as a cortisol will have to battle against the procytakine effects of endotoxin which is already in the blood. It turns out in this case specifically that the latter takes over.