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#133 – Manolis Kellis: Biology of Disease
Lex Fridman Podcast
The Path Between Genetics and Gene Expression
The path between genetics and diseases is enormous, but we can break it up to look at the path between Genetics and gene expression. So instead of using Alzheimer's as a phenotype, I can now use expression of IRX3 as the phenomenon. The CRISPR system will basically use this guide RNA, scan the genome, find wherever there's a match, and then cut the genome. When bacteria are constantly attacked by viruses,. But sometimes they win against the viruses and they remember as a trophy inside the genome, this CRISPR structure that stands for clustered interspersed repeat regions.
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