Clinical Scenario and Pharmacokinetics of Frasimide

This chapter explores the clinical scenario of a 75-year-old male in ICU with respiratory distress and hypoxemia, focusing on frasimide, a loop diuretic that induces diuresis by blocking the sodium-potassium-chloride transporter in the thick ascending loop of Henle. It delves into the pharmacokinetics of frasimide, discussing its bioavailability, onset of action, metabolism, and potential side effects like hypokalemia and metabolic alkalosis.