How to Add an IO to a Patient With Metastatic MSI High Disease

In a patient that's basically going to recur and die for sure, I'm probably going to give her the best chance now with a triplet regimen. But in the lower risk patient, I'm going to do really what is sequence, give them carboplatin pakletaxle if they're PMMR. Then when they recur, but that's rare because we cure a lot of patients with oligometastatic disease, then I can give them Pembro-Lizumab then.