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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity
Huberman Lab
The Effects of Ketamine on Neuroplasticity
Ketamine binds to the NMDA receptor present on inhibitory neurons. In doing so, it dramatically reduces the amount of inhibition coming from those inhibitory neurons onto excitatory neurons. When that happens,excitatory neurons in specific circuits of the brain are allowed to increase their activity. They do what's called bursting. Bursting patterns of electrical activity induce long term changes in neural circuits associated with reward, with dopamine release, and with mood.
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