Prognostic significance of splicing factor gene mutations in AML; therapy resistance in multiple myeloma; the effects of KIT ligand deletion on HSC homeostasis
Blood Podcast
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Investigating Subclones and Treatment Resistance in Multiple Myeloma
This chapter discusses the findings of a study on relapsed refractory multiple myeloma patients, where subclonal evolution patterns and resistance mechanisms were identified. The authors emphasize the importance of integrative multi-omics analysis in identifying molecular targets against drug-resistant subclones.
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