The chapter explores the activation and remodeling of the neuroendocrine system in women during puberty, pregnancy, and menopause, focusing on brain health and emotional well-being. It discusses the impact of menopause on cognitive health, the lack of research and support for women's brain health during this phase, and the differences in societal attitudes towards menopause. The importance of lifestyle choices, avoidance of smoking, and the long-lasting effects of such decisions on brain health are emphasized, along with personal reflections on smoking and its implications for women's brain aging.

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