Surge in Syphilis Diagnoses and Neurosyphilis Challenges

This chapter examines the alarming 80% increase in syphilis diagnoses in the U.S., with a focus on a 180% rise in congenital cases over five years. It discusses the complexities of diagnosing neurosyphilis, emphasizing the role of lumbar punctures and cerebrospinal fluid testing amidst rising neurological complications. The chapter highlights the limitations of current diagnostic markers and the ongoing quest for a reliable biomarker for neurosyphilis.