Brain Ponderings podcast with Mark Mattson cover image

How the Brain Decodes Odors and Computational Neuroethology with Bob Datta

Brain Ponderings podcast with Mark Mattson

00:00

The Evolution of SARS-CoV-2 Infection

A lot of the confusion about how SARS-CoV-2 affects smell comes from the fact that it doesn't really affect mice. So what people have done is they've genetically engineered mice to express ACE2 in all neurons. And if you take a mouse in which ACE2 is expressed everywhere and you give it COVID, then all the neurons that are topically expressing ACE2 get infected. But at the beginning of the pandemic, there was a lot of confusion because mice don't really get infected. The best rodent model we have is the Golden Hamster, which actually gets extracted quite readily. It's been used to model the evolution of SARS- CoV-2

Transcript
Play full episode

The AI-powered Podcast Player

Save insights by tapping your headphones, chat with episodes, discover the best highlights - and more!
App store bannerPlay store banner
Get the app