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#133 – Manolis Kellis: Biology of Disease
Lex Fridman Podcast
How to Generate 10,000 Different Versions of an Encoder?
In the common plasmid, it's all the same before you added it. The rest of the plasmid is the same. So it's called an epizomal reporter assay. Epizome means not inside the genome, it's sort of outside the chromosomes. And those 10,000 can be 5,000 of different loci and each of them in two versions, risk or non-risk. I can now test tens of thousands. These are little hypotheses. Exactly. And then you can do 10,000 and wait. You can test 10,000 hypothesis at once. Trivial. But it's biology.
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