The Role of Volume Depletion in Metabolic Alkalosis

We often use alkalosis as like a proxy for maybe we need to stop diarheasing. And this suggests, assuming that there's nothing else involved, that you have made the person indeed volume depleted if they've managed to maintain an alkalosis in some kind of sustained manner. But what's really important and something that I only got insights on in reviewing this topic is that the volume depletion alone may not be enough to correct the metabolic alkalosis. The macular densa actually senses chloride was totally eye opening to me.