Complement
ACR Journals On Air
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The Significance of Low Levels of Circulating C3 and C4
The chapter explores the significance of low levels of circulating C3 and C4 in the clinical arena, explaining that while it is always abnormal, it may not necessarily indicate a pathogenic condition. It delves into the complexities of the C4 gene and its impact on lupus. The chapter also discusses acquired causes of low complement protein production and the usefulness of laboratory testing.
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