The Importance of Speculating

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In 2011, 10 years after the initial reports that animals sirtu in genes are anti-aging genes, a group of investigators were able to publish a paper saying fly and worm sirtu over expression does not extend lifespan. "I saw the low quality of data being examined at Sertris," says Dr. Richard Branson. Rizvara Trol is not an activator of these genes. And as you know, Sertuans are a failed drug target because they're not longevity genes.

Episode #272. In the quest for an extended lifespan, has science been led astray? Join me as I sit down with Professor Charles Brenner, a leading global expert in NAD biology, to examine the longevity field's claims and controversies.

From debunking common beliefs to questioning high-profile opinions, Dr Brenner delivers a refreshingly candid perspective on the science of aging. Tune in to explore why he believes there's no “cure” for aging, the limitations of animal studies, and what the future might hold for this complex field.

Specifically, we discuss:

Intro (00:00)
Do we have the genes to live beyond 120 years? (3:54)
The genetics of extreme longevity (14:18)
Longevity in the animal kingdom (18:26)
Why do we age, and the realities of extending lifespan (31:22)
How long can we live? (39:01)
NAD coenzymes and DNA repair (43:49)
"Anti-ageing" products (55:17)
Conflicts of interest and the integrity of scientific claims (1:01:08)
Discovering nicotinamide riboside (NR) (vitamin B3) (1:03:19)
Sirtuins as anti-ageing genes (1:09:22)
A rebuttal to Drs. David Sinclair and Lenny Guarente (1:19:13)
Seeking consensus on the study of human longevity (1:32:57)
The information theory of aging (1:43:19)
Dr. Charles Brenner's theory of ageing (2:00:28)
How to age better (2:03:30)
Dr. Brenner on the quality of life (2:09:05)
NR supplementation (2:10:09)
Moving beyond Yamanaka factors (2:15:02)
Outro (2:18:45)

Connect with Dr Charles Brenner on Twitter, and visit his website, https://www.brennerlab.net/, for more.

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Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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