Microbiome Influence on Offspring Health in Male Mice

In this episode:

00:46 Using genomics to explain geographic differences in cancer risk

The risk of developing cancer can vary hugely depending on geographic region, but it’s not exactly clear why. To get a better idea, a team has compared the genomes of kidney cancers taken from people around the globe. They reveal a link between geographical locations and specific genetic mutations, suggesting that there are as-yet unknown environmental or chemical exposures in different locations. They hope this work will inform public health efforts to identify and reduce potential causes of cancer.

Research Article: Senkin et al.

News and Views: Genomics reveal unknown mutation-promoting agents at global sites

07:46 Research Highlights

Research reveals that the extinct ‘sabre-toothed salmon’ actually had tusks, and a common fungus that can clean up both heavy-metal and organic pollutants.

Research Highlight: This giant extinct salmon had tusks like a warthog

Research Highlight: Garden-variety fungus is an expert at environmental clean-ups

09:55 How disrupting a male mouse’s microbiome affects its offspring

Disruption of the gut microbiota has been linked to issues with multiple organs. Now a team show disruption can even affect offspring. Male mice given antibiotics targeting gut microbes showed changes to their testes and sperm, which lead to their offspring having a higher probability of severe growth issues and premature death. Although it’s unknown whether a similar effect would be seen in humans, it suggests that factors other than genetics play a role in intergenerational disease susceptibility.

Research article: Argaw-Denboba et al.

News and Views: Dad’s gut microbes matter for pregnancy health and baby’s growth

17:23 Briefing Chat

An updated atlas of the Moon that was a decade in the making, and using AI to design new gene-editing systems.

Nature News: China's Moon atlas is the most detailed ever made

Nature News: ‘ChatGPT for CRISPR’ creates new gene-editing tools

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