Evolution of Cephalosporins: From Past to Present

This chapter provides a comprehensive exploration of the history and development of cephalosporin antibiotics, starting from the first discovery in 1948 to the latest fifth-generation cephalosporin Keftera. The discussion covers the classification into generations, mechanism of action, spectrum of coverage against various bacteria, and the challenges and advancements in prescribing practices over time. It also highlights the evolving nature of antibiotic generations and the unique properties of newer cephalosporins like Kefideracol.