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#31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease

The Peter Attia Drive

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Met Foreman - Is Complex One Refractory?

Yeast has a protein, single protein, which will catalyze any d h to an d ok. We have engineered cells and mice to get rid of complex one and put back this yeast complex one, which is refractory. It doesn't contribute to a t p generation but it does the electron transport. So you've basically reduced your battery charge a little bit, a littlebut you haven't interrupted the electron transportr. That's very elegant. Yes. Thiss about the geekiest moment, right? Nis liketi ets one of those d things. Rit is clever. S very clever. Sit ta, you put.

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