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TWiV 967: Clinical update with Dr. Daniel Griffin

This Week in Virology

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Vaccination and Immunodominant Response

Vaccination is obviously reducing the amount of virus replication. So you're not getting a good response to nuclear caps, which is the most abundant viral protein. Imprinting is not even relevant because it's a conserved protein. It doesn't change in the variants whatsoever, not significantly. The only thing I can think of is that if you're vaccinated, you're getting so much less reproduction that you don't get a good antibody. But anyway, Daniel, what can you use for surveillance then? Because you need to use a serological test because PCR is too transient, right? Yeah.

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