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245 | AI Tsunami warning! 11 % of jobs replaceable today, CEOs admit 20 % staff over-capacity, Claude 4.5 outcodes humans, Harvard’s PopEVE cracks rare genes and more AI news for the week ending on Nov 28, 2025

Leveraging AI

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Anthropic releases Claude Opus 4.5 improvements

Isar details Opus 4.5's performance, pricing, effort parameter, benchmarks, and alignment improvements.

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