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17min chapter
#181 – Laura Deming on the science that could keep us healthy in our 80s and beyond
80,000 Hours Podcast
Manipulating Lifespan Through Genetics and Biology
The chapter explores the potential of extending lifespan by manipulating specific genes and biological pathways, using examples like removing senescent cells and utilizing drugs such as rapamycin and metformin to increase longevity in animals. It discusses the complexities of aging processes, including caloric restriction, insulin signaling, and the impact of genetics on lifespan, shedding light on the varied theories and lack of comprehensive understanding in this field. The conversation touches on cutting-edge research areas such as parabiosis and highlights the importance of advancements in biology tools for future longevity interventions.
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