The Role of Interferon in Polycytemia Veera

Dr. Kazola: I fully agree with you that mutant allele burden is really an important rhinostic factor in polycytemia veera. In my own patients, I have many who now have achieved this colonal suppression as reflected by Jack to a wheel burden reduction of 80%. And over five years, they have now come to allelic burdens below 5%, or below 10% some level. The most recent update of the PRAU PV trial showed that after seven, by seven years now, there was definitely a significant difference of a combined endpoint of disease progression, thrombosis, or death.