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PROTACs Roundtable: Bertozzi and Deshaies

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Is Induced Proximity a Drug Development Approach?

The hand that grabs your target molecule doesn't really need to be an inhibitor. That's absolutely key to the idea rit is that it frees you from the constraint of having to find a molecule that modulates the activity of the target. With induced proximity, that constraint is completely removed. Now all the drug has to do is touch the target, is hold on to the target, grab the rget anywhere,. Whether that has a functional impact or does not have a functional impact, because the drug is actually pre existing in the cell. It's a nor it's a natural mechanism. Or even outside the cell, its a natural mechanism within the body that will modulate the activity of

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