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Estrogen and Menopause
The biggest problem with these type of hormone replacements was that estrogen itself is three types of estrogen. By far, the most active is 17 beta estradiol. That hormone has the distinction of being the only hormone that's recognized as a carcinogen,. It's known to stimulate cancers of the breast uterus and possibly prostate. If you balance out the estrogen by adding some progesterone it more or less neutralizes the cancer effect.