All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev

Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.

Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.

It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld

Find me on Twitter: https://twitter.com/livelongerworld

VADIM GLADYSHEV LINKS:

Website: https://gladyshevlab.bwh.harvard.edu/2022

Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1

LIVE LONGER WORLD LINKS:

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS:

0:00 Vadim Gladyshev Intro

1:28 Live Longer World

2:17 Selenium’s dual role in aging (the good, the bad, the ugly)

11:27 Antagonistic Pleiotropy

13:53 Selenium & Cancer

15:58 Selenium Dosage (don’t get too much!)

18:30 Reactive Oxygen Species, Antioxidants & Aging

22:30 Fundamental basis of Aging

24:09 Aging is damage

29:20 Single cell Epigenetic Clocks

34:22 Aging in the Womb

42:16 Parent’s lifestyle for aging in embryo

44:14 Rapamycin during development

49:06 Other compounds

51:53 Slowing Aging vs. Rejuvenation

56:08 New projects being worked on

57:17 Confidence level in extending lifespan within 30 years

59:17 Support Live Longer World

Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev

Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.

You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.

Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

The Call to Commitment - Part 1

Daily Radio Program with Charles Stanley - In Touch Ministries

Hearing God Requires Attention

The AI-powered Podcast Player