There's been more than 60 clinical trials investigating the effects of isoflavones on symptoms and hot flushes in particular. Now some show a benefit but some don't. And if we try and work out what's going on by looking at all of these trials together what we see is that the type and also the dose ofIsoflavones is important. Some individuals respond more than others to isoflavone. This is because the gut microbiome is involved in metabolizing them into their very active form called echol.

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