In cancer, we're always concerned with the malignant aspect of this growth that's out of control. But you have to also realize that the organelle inside the cell that's responsible for oxidative phosphorylation is the mitochondria. When that organelle becomes defective, you get two things: The cell is fermenting and proliferating at the same time. And it happens slowly, gradually. As the waste products of fermentation are lactic acid and succinic acidification of the microenvironment, which then feeds back further damaging oxidative phosphorylated cells. Leading to a dysregulated cell growth,. A change in the microenvironmentwhich then feeds forward to continue this abnormal growth.

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