REBEL Cast Ep 118: The PROCOAG Trial – 4F-PCC for Trauma Patients?
REBEL Cast
00:00
The Benefits of Early Administration of Four Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion
Bousat P et al. Efficacy and safety of early administration of four factor prothrombin complex concentrate in patients with trauma at risk of massive transfusion, the procoag randomized trial published in JAMA 2023. Swami: We've become very enamored by PCCs because of the lab values that they kind of quickly reverse. But we really have to get some hard data telling us that this is better for our patients because these drugs aren't cheap.
Transcript
Play full episode
Background: Hemorrhage is the leading cause of mortality in trauma patients. Interventions such as early application of hemorrhage control, tranexamic acid, reduction of crystalloid fluid administration and balanced ratio blood product transfusion have improved many patients’ outcomes. However, mortality still remains high due to trauma-induced coagulopathy. Some clinicians have advocated for early administration of 4-factor ... 
