Ali Madani on Biology Models and ProFluent

• (01:04) - iMessages in Gemini 3
• (10:52) - 𝕏 Timeline Reactions to Gemini 3
• (28:29) - 𝕏 Timeline Reactions
• (01:05:11) - CloudFlare Outage
• (01:16:16) - Byrne Hobart on the Upsides of Bubbles
• (01:30:12) - Byrne Hobart is an investor, consultant, and writer, best known for his newsletter "The Diff," which explores inflection points in finance and technology. He is also a partner at Anomaly, a frontier tech investment firm, and co-authored "Boom: Bubbles and the End of Stagnation," published by Stripe Press in November 2024. In the conversation, Hobart discusses the role of financial bubbles in driving innovation, arguing that while often viewed negatively, bubbles can coordinate market participants to overbuild infrastructure, thereby laying the groundwork for future technological advancements.
• (02:06:34) - Glenn Hutchins, co-founder of Silver Lake Partners and chairman of North Island Ventures, discusses his career trajectory, highlighting his roles at Thomas H. Lee Partners, the Clinton administration, Blackstone Group, and the founding of Silver Lake in 1999. He emphasizes the evolution of private equity, noting key financial innovations like the capital asset pricing model and Black-Scholes option pricing, which enabled the valuation and financing of technology companies. Hutchins also addresses the rapid growth and capital demands of AI infrastructure, comparing it to historical technological shifts, and underscores the importance of strategic investment and adaptability in the face of evolving market dynamics.
• (02:35:17) - Yogi Goel, founder of Maxima, an enterprise accounting platform, discusses their recent $41 million funding round and how their AI-driven system integrates with existing ERPs to automate financial processes and detect anomalies, aiming to reduce errors and inefficiencies in accounting.
• (02:40:40) - Sam Jones, CEO and co-founder of Method Security, announced the company's $26 million combined seed and Series A funding from Andreessen Horowitz and General Catalyst. He discussed the increasing use of AI in cyberattacks, emphasizing the need for autonomous systems to enhance cyber resilience. Jones highlighted Method Security's dual-use approach, serving both government and commercial sectors, and shared his background in cyber operations with the U.S. Air Force and experience at Palantir.
• (02:47:50) - Ali Madani, founder and CEO of Profluent Bio, discusses his background in machine learning and biology, highlighting his PhD from UC Berkeley and his leadership in developing language models for biology at Salesforce. He explains Profluent's mission to make biology programmable by using AI to design bespoke medicines, moving away from traditional random discovery methods. Madani also shares the company's progress, including the development of OpenCRISPR-1, an AI-generated gene-editing protein, and mentions securing $106 million in funding from notable investors like Jeff Bezos.
• (02:56:08) - Amit Jain, CEO and Co-Founder of Luma AI, announced that the company has raised a $900 million Series C funding round led by Saudi Arabia's state-backed AI firm HUMAIN, valuing Luma AI at over $4 billion. Additionally, Luma AI and HUMAIN are collaborating to build a 2-gigawatt compute cluster in Saudi Arabia, named Project Halo, to train multimodal artificial general intelligence (AGI) models. Jain emphasized the necessity of integrating text, audio, video, and images to develop AI systems capable of understanding and simulating the physical world, highlighting the importance of multimodal models in advancing AI capabilities.

TBPN.com is made possible by: 

Ramp - https://ramp.com

Figma - https://figma.com

Vanta - https://vanta.com

Linear - https://linear.app

Eight Sleep - https://eightsleep.com/tbpn

Wander - https://wander.com/tbpn

Public - https://public.com

AdQuick - https://adquick.com

Bezel - https://getbezel.com 

Numeral - https://www.numeralhq.com

Polymarket - https://polymarket.com

Attio - https://attio.com/tbpn

Fin - https://fin.ai/tbpn

Graphite - https://graphite.dev

Restream - https://restream.io

Profound - https://tryprofound.com

Julius AI - https://julius.ai

turbopuffer - https://turbopuffer.com

fal - https://fal.ai

Privy - https://www.privy.io

Cognition - https://cognition.ai

Gemini - https://gemini.google.com

Follow TBPN: 

https://TBPN.com

https://x.com/tbpn

https://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231

https://podcasts.apple.com/us/podcast/technology-brothers/id1772360235

https://www.youtube.com/@TBPNLive