4min chapter

The Curbsiders Internal Medicine Podcast cover image

#386 Primary Aldosteronism, MRAs, and Renovascular Hypertension: NephMadness Pod Crawl 2023

The Curbsiders Internal Medicine Podcast

CHAPTER

Is Pleyranone a Good Alternative to Spironolactone?

Pleyranone is a little bit more selective, right? So less side effects. I read it has to be dosed twice a day. What does the dosing and titration, what's it like for that one? Yeah, ideally twice a day, I basically double the dose of spironolactone. But they definitely need it at those doses, but you start getting just incredible pushback from pharmacy and people paying for the medicine. And actually for this particular patient who has diabetes and some challenging blood pressure with albium anuria, this might be indicated.

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