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Programming Medicine with Dr. Jonathan Weissman

FYI - For Your Innovation

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The Importance of Using CRISPR to Generate Hypotheses

Knowing better what changes are going to impact the disease process will be central to making better therapies. CRISPR type tools that let us make these changes, either in cells or increasingly in animal models, mice, but even in more sophisticated models like non-human primates is an important part. Drug targets that are validated by human genetics have an enormous advantage over ones that are just based on work we do in a dish or in an animal model. But for the time being there's going to be an important role for small molecules and protein drugs.

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