The Role of TMS in the Treatment of Depression and Addiction

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There is room for potentially stripping out some of the psychedelic effects, but we need to keep in mind that the business motivations may not always be aligned with clinical outcomes. I wanted to shift to TMS and deep brain stimulation. We were talking about sort of different activity or maybe pathological activity in different neuroanatomical structures. The nucleus accumbens is one of the main targets,. both for depression as well as for addiction. But there are other neuromodulation technologies. So transcranial magnetic has my brain even more excited than TMS.

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Nora D. Volkow, MD, is Director of the National Institute on Drug Abuse (NIDA) at the National Institutes of Health. NIDA is the world’s largest funder of scientific research on the health aspects of drug use and addiction. Dr. Volkow's work has been instrumental in demonstrating that drug addiction is a brain disorder. As a research psychiatrist, Dr. Volkow pioneered the use of brain imaging to investigate how substance use affects brain functions. In particular, her studies have documented how changes in the dopamine system affect the functions of brain regions involved with reward and self-control in addiction. She has also made important contributions to the neurobiology of obesity, ADHD, and aging.

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[06:09] Cadaver homework.

[09:07] The Trotsky connection.

[17:07] How Nora’s father viewed the role of science.

[20:59] Julian Villarreal.

[27:38] A perspective of perseverance.

[33:48] Instilling perseverance in younger scientists.

[35:08] Dancing with Demerol.

[40:05] The current state of addiction in the US.

[44:28] The War on Drugs.

[49:42] Increasing societal confidence in therapeutic psychedelics.

[55:38] Advice for researchers seeking more federal funding.