The Role of Cytochrome P450 Genes in Drug Metabolism

This chapter explores the cytochrome P450 network of genes and its impact on drug metabolism. The speakers highlight the importance of specific genes, such as CYP2D6, CYP2C9, and CYP2C19, and discuss the prevalence of gene mutations in different populations.

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In 2011, a paper was published in Pharmacogenomics and Personalized Medicine examining the relationship of antidepressants and akathisia side effects in those with genetic mutations in the metabolizing genes of the CYP450 family. In the study, eight of the subjects had committed homicide and many more became extremely violent while on antidepressants.

On today’s podcast we welcome one of the co-authors, Christopher Crotty, and subject, David Carmichael, to share their stories.

Note: This podcast episode is designed solely for informational and educational purposes, without endorsing or promoting any specific medical treatments. We strongly advise consulting with a qualified healthcare professional before making any medical decisions or taking any actions.

*If you are in crisis or believe you have an emergency, please contact your doctor or dial 911. If you are contemplating suicide, call 1-800-273-TALK to speak with a trained and skilled counselor.

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ADDITIONAL RESOURCES

Lucire, & Crotty, C. (2011). Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP450 family. Pharmacogenomics and Personalized Medicine, 65. https://doi.org/10.2147/pgpm.s17445

16:00 Zhou, Y., Ingelman-Sundberg, M., & Lauschke, V. (2017). Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects. Clinical Pharmacology & Therapeutics, 102(4), 688–700. https://doi.org/10.1002/cpt.690

30:00 - Know Your Drugs

39:30 - David Carmichael v. GlaxoSmithKline Inc.

40:00 - Carmichael, D. Calm, organized, homicidal behaviour – my connection to school shooters. Mad In America.