The Role of Renal Function in End Stage Renal Disease

Direct oral anticoagulants have shorter half lives than warfarin and so you need to stop them much less time before but it's very dependent on renal function. For patients who are low risk surgery or have no patient risk factors then the recommendation just as with VKA's vitamin K antagonist is not to stop at allso keep them on it. But what you would do is give it during the trough of their dose obviously this doesn't apply to warfarin there is no trough when someone is on a long acting agent like warfarin but for these because they're much shorter acting you do have a trough.