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HER3: A Vital Target in Cancer Treatment
Oncotarget
Challenges in Translating Preclinical Studies on HER3 Targeted Therapies to Clinical Trials
Exploring the challenges in translating preclinical studies on HER3 targeted therapies to clinical trials, including the lack of HER3 expression screening in previous trials. Emphasizing the importance of identifying HER3 expression and gene fusions as predictive biomarkers and discussing alternative HER3 activating mechanisms and compensatory tumor cell responses.
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