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EB. 113: Carbohydrates Don’t Cause Insulin Resistance or Diabetes; Evidence For The Bioenergetic View

The Energy Balance Podcast

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Insights into Glucose Metabolism and Insulin Resistance in Diabetes

Detailed analysis of glucose metabolism in insulin-resistant individuals, focusing on inhibited glucose oxidation and favored glycolysis and fat oxidation. The chapter explores the mechanisms of impaired glucose oxidation, the role of insulin in regulating fatty acid oxidation, and challenges the idea of metabolic flexibility in diabetes. It discusses a study on enzyme activity levels in skeletal muscle, highlighting the correlation between enzyme imbalance and insulin sensitivity, pinpointing mitochondrial dysfunction as the central issue in insulin resistance.

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