How carbs affect anabolic signaling and partitioning

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This week on the podcast, Mikki speaks to returning guest Brandon DaCruz — coach, educator, and one of the sharpest minds in physique and performance nutrition. Their conversation takes a deep dive into nutrient timing: what actually matters, what’s been overstated, and where the science genuinely shifts outcomes in the real world.

Brandon unpacks the long-debated “anabolic window” and why it’s not as binary as social media makes it seem. He and Mikki explore how pre- and post-workout nutrition can affect not just muscle protein synthesis but muscle protein breakdown, training volume, recovery, appetite regulation, energy expenditure, and even how the body partitions fuel toward muscle or fat. They look at insulin sensitivity around training, cortisol’s role in extended sessions, and how to structure peri-workout nutrition differently for fat loss versus muscle building. They also discuss carbohydrate timing, intra-workout fuelling, and the most persistent myths that still mislead lifters today.

A conversation for anyone who wants to train smarter, not just harder — and understand the metabolic choreography that happens behind the scenes of every rep.

Brandon DaCruz at his website https://www.brandondacruzfit.com/, and on Instagram @brandondacruz_

Chasing Clarity https://podcasts.apple.com/us/podcast/ep-112-spot-reduction-is-it-possible-to-lose-body-fat/id1619611966?i=1000657394910

Brandon DaCruz is an online nutrition and physique coach and sports nutritionist. He’s also a National Level NPC physique competitor and an internationally published fitness model who’s written articles and filmed educational content for publications like Men’s Fitness Magazine and Bodybuilding.com. 

Brandon has spent over 13 years  working within the sports nutrition and fitness industries and has coached every type of client including Olympia Level professional men’s physique competitors, college athletes, MMA fighters, CrossFit competitors, and lifestyle clients. 

He believes in blending what’s been proven in the research with his own anecdotal and first hand "in the trenches'' experience to improve body composition, optimise performance and enhance health in order to help his clients achieve their goals whether that be building muscle, losing body fat, increasing performance and/or optimising health and longevity. This is what he refers to as his health-centric coaching model as he believes that improving one's health is the cornerstone to optimising their physical goals. 

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