The Amyloid Cascade Hypothesis and Alzheimer's Disease

The small to non-existent effect sizes in these trials and earlier ones suggests that amyloid plaques are not the cause of Alzheimer's disease. Ralph Nixon: The impact is so minuscule, you're using the lowest possible bar I can think of. Scott Small calls amyloid more the smoke than the fire. Donald Weaver: To date, it has not yielded a meaningful therapeutic.