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Audio long read: How your first brush with COVID warps your immunity
Nature Podcast
The Imprinting Effect on the Immune System
Memory B cells can mutate, to some extent, when exposed to a new strain. This process is known as affinity maturation. The transformation occurs in transient structures in the lymph nodes - called terminal centers. Researchers have also looked at whether the immune system can deploy entirely new B cells when faced with a new infection.
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