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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity
Huberman Lab
The Role of Ketamine in Relief From Depression
When people were given ketamine, they got relief from depression. Many studies had shown that before since the early 2000s. If however, individuals were given naltrexone to block the opioid receptor pathway and they were given Ketamine, well, then the antidepressant effects of ketamine were no longer observed. Now that suggests that it is the opioid receptor system that's responsible for the antidepressant effect of ketamine. And perhaps this HNK, this hydroxynor ketamine, is the way in which ketamine normally relieves depression.
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