In this episode I sit down again with microbiome researcher Dr Suzanne Devkota to explore what a healthy microbiome really is and how we can support it. We unpack diversity, early life programming, fibre and microbiota accessible carbohydrates (MACs), plus the genuine role of probiotics, prebiotics and postbiotics.

Suzanne also shares cutting edge research on short chain fatty acids, Akkermansia, inflammatory bowel disease, visceral fat and colon cancer, and helps separate solid science from the noise you see online.

What We Cover

What the microbiome is and how it differs along the digestive tract
Why diversity is a key marker of gut health and how chronic disease and diet affect it
Early life influences on the microbiome, from birth mode to first foods
The realities of stool testing, different methods, and how to interpret results with care
Probiotics versus prebiotics versus postbiotics, when each may or may not be useful
MAC rich foods, short chain fatty acids and why butyrate is so important for gut barrier integrity
The Akkermansia story, mucus, leaky gut and why focusing on one bug is misleading
New data on IBD, gut leakiness, bacteria in fat tissue and links to fibrosis and metabolism

I hope this conversation gives you a clearer, more grounded view of gut health and helps you focus on practical, sustainable steps that genuinely support your microbiome.

You can learn more from Dr Suzanne Devkota by following her on Instagram, or by visiting the Cedars-Sinai Human Microbiome Research Institute and the Devkota Lab.

Intro (00:00:00)
The Microbiome Conversation (00:01:16)
How Diversity Shapes Your Gut’s Health and Resilience (00:04:40)
The First Three Years That Shape a Lifetime (00:08:09)
What Microbiome Tests Can and Can’t Tell You (00:11:05)
Probiotics, Prebiotics, Postbiotics (00:18:05)
The Quiet Power of Short-Chain Fatty Acids (00:34:47)
The Fiber Controversy and What People Get Wrong (00:47:58)
How Daily Habits Quietly Reshape Your Microbiome (00:49:28)
Antibiotics, Resetting, and Rebuilding Your Gut (00:52:07)
How Early-Life Factors Imprint Your Gut for Decades (00:56:57)
Why Chronic Inflammation and IBD Connect Back to the Microbiome (01:03:14)
What We’re Learning About Colon Cancer and the Gut (01:16:13)
The Future of Microbiome Science and Personalized Gut Care (01:27:45)

This episode is brought to you by:

38TERA

Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

Function Health

Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

Eight Sleep

Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $400 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping.

Momentous

My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.

Simon Hill, MSc, BSc (Hons)

Subscribe & Connect:

Episode 262: Daniel Winter-Bates (Bury Tomorrow)

Mark and Me Podcast

What keeps the hunger alive

The AI-powered Podcast Player