A weak acid will, in a solution, donate some hydrogen ions. That's what it does, donates H pluses. And it's left as a negative charge, the chemical. A strong acid means it releases all of the hydrogen ions,. readily, just throws them off. The drug is now left with the charge, and it's ionized. Yeah, it has a reduced capacity to be absorbed. So the drug then becomes ionized. Lipid membranes do not let anything through that's large or charged. When you think about a charged molecule, like an ionized drug, for example, it's not gonna get through... It's gonna be stuck in that area in which