Metformin Therapy and Type 2 Diabetes Mellitus in Patients With Prediabetes

A Cochrane review found 20 RCTs studying progression to diabetes. In these trials, it was found that Metformin was more effective with a relative risk of 0.5. What if we focus in based on the patient's starting risk? The Diabetes Prevention Program looked at patients with risk factors for Type 2 diabetes.