4min chapter

FYI - For Your Innovation cover image

Inventing Base Editing with Doctors Nicole Gaudelli and Alexis Komor

FYI - For Your Innovation

CHAPTER

Is It Possible to Build a Molecule in a Molecule?

Alexis Cai: Do you guys think that being chemist, you came from a different angle and it allowed you to see things differently just to garner a different approach? Cai: Yeah, absolutely. That was like the key difference there. And we were able to basically like predict what the base editing window would be just by staring at crystal structures and stuff. I spent a good six months characterizing the system in vitro, trying to figure out what was going on.

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