TWiV 1191: The pandemic duo
This Week in Virology
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ISG15 and Viral Defense in Bats
This chapter discusses the pivotal role of ISG15, a small protein, in antiviral responses during viral infections, particularly in bats. It highlights genetic modifications in bat species that affect ISG15's functionality against different viruses, focusing on the implications of specific mutations like cysteine 78. The exploration of immune adaptations in bats reveals complexities in balancing antiviral efficacy and inflammation, as well as the relevance of these findings to human immune diversity.
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