In this episode, Dr. Colleen Cutcliffe, CEO and co-founder of Pendulum, delves into the vital role of the gut microbiome and Pendulum's innovative products in optimizing metabolic health. She discusses the significance of the gut microbiome in metabolic health, immune function, and beyond. Dr. Cutcliffe offers practical advice for individuals navigating antibiotic treatments and emphasizes the importance of choosing high-quality probiotic supplements. Furthermore, she underscores the benefits of continuous glucose monitors and explores the possible synergies between Pendulum's Glucose Control and GLP-1 medications such as Ozempic for enhanced outcomes. Additionally, she outlines Pendulum's research focus on improving gut metabolism and elucidating the gut-brain connection as promising avenues for future intervention.

Takeaways

• The gut microbiome plays a crucial role in metabolic health, cardiovascular health, immune response, and brain health.
• Microbiome transplants have shown promise in treating obesity and other health conditions.
• Antibiotics and diet can significantly impact the composition of the gut microbiome.
• Probiotics and prebiotics can help restore and support a healthy gut microbiome.
• Pendulum's glucose control product has been shown to lower A1C and blood glucose spikes in people with type 2 diabetes.
• Continuous glucose monitors provide valuable data on how different foods affect blood glucose levels.
• Combining Pendulum's glucose control with GLP-1 medications may offer additional benefits.
• Pendulum is focused on ongoing research and development to improve metabolic health and support patients in transitioning off medications.

00:00
Introduction and Background
02:01
Pendulum's Journey and Products
04:30
What is Akkermansia?
06:43
The Importance of the Gut Microbiome
09:22
Microbiome Transplants and Obesity
14:12
Factors Affecting the Microbiome
16:12
Recovering from Antibiotic Use
18:25
Probiotics and Prebiotics
20:07
GLP-1 and Pendulum's Approach
28:53
Pendulum's A1C Study
30:41
CGM and Glucose Control
33:00
Weight Loss and Glucose Control
35:21
Butyrate and Butyrate Supplements
36:30
Future Research and Conclusion
42:11

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Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation

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