In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman discuss the complexities of cancer with Dr. Joe Zundell, a cancer biologist. They explore the definition of cancer, its prevalence, and the hallmarks that characterize cancer cells. The conversation delves into the mechanisms of cancer growth, including sustaining proliferative signaling, evading growth suppression through the P53 gene, and the process of apoptosis. The discussion aims to make these complex topics accessible to a broader audience while highlighting the importance of understanding cancer biology. In this conversation, Dr. Joe Zundell discusses the complexities of cancer biology, focusing on key hallmarks such as immune response, replicative immortality, angiogenesis, and metastasis. He emphasizes the importance of early detection and the challenges of targeting cancer cells without affecting healthy cells. The discussion highlights the need for careful consideration of information regarding cancer treatment and the significance of working with healthcare professionals.
All our sources from this episode are available at: https://www.unbiasedscipod.com/episodes/
(00:00) Introduction
(05:28) Understanding Cancer: Definitions and Statistics
(10:15) The Hallmarks of Cancer: An Overview
(15:14) Sustaining Proliferative Signaling in Cancer
(20:07) Evading Growth Suppression: The Role of P53
(25:17) Apoptosis: The Controlled Cell Death Mechanism
(30:21) Understanding Cancer: Immune Response and Cell Death
(33:31) Replicative Immortality: The Hayflick Limit
(38:27) Angiogenesis: Blood Vessel Formation in Tumors
(46:32) Invasion and Metastasis: The Spread of Cancer
(54:22) Final Thoughts: The Complexity of Cancer Treatment and Early Detection
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