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55. Macrophage Activation Syndrome

ACR on Air

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The Role of Genetics in MAS

You can never really eliminate an infection in cells, right? Your T cells are, you know, there's a class of T cells called executioners. Their job is to execute, get rid of infected cells. If you can never do that, like the infection ever goes away, right? Yeah. Get antigen stimulation, continued activation. In other people, they just have a lot of inflammation like our kids with systemic juvenile, idiopathic arthritis,. They're just really inflamed. A lot of IL-1, IL-6, these inflammatory messages and that chronic activation can lead to a mass. And then really bad infections can, youknow, like the classic one is mono

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