Individual Differences: Receptor Distribution and Treatment Response

Check out Sentia Spirits the future of drinking (Use Code GIANT10 for 10% discount off your first purchase: https://sentiaspirits.com/mcgloughlin4209355084Adam Safron is a cognitive neuroscientist and former research fellow at Johns Hopkins’ Center for Psychedelic & Consciousness Research, now a staff scientist with Michael Levin at Tufts’ Allen Discovery Center. He’s the architect of the Integrated World Modeling Theory of consciousness and known for provocative work on rhythmic neural entrainment in trance and orgasm.Psychedelics don’t just make you see things — they loosen high-level assumptions in the brain’s predictive model, opening a window for insight, flexibility, and lasting change. We connect this to the Free Energy Principle, the brain’s inner “movie screen,” and why rhythm, attention, and context can shift who we are and how free we feel.Expect to learn what the Free Energy Principle really means in plain English, how generative models, prediction errors, and precision shape perception and action, why the precuneus/PCC may serve as an inner canvas for conscious scenes, the difference between posterior stream and prefrontal access (continuous experience vs discrete sharing), how psychedelics via 5-HT2A and REBUS/ALBUS relax some priors (and strengthen others), why set and setting and mystical-type experiences predict outcomes, how trips can increase “degrees of freedom” (a practical take on free will), what rhythmic entrainment reveals about flow, meditation, and orgasm, what DMT’s “entities” might say about world-models, how bioelectric intelligence informs consciousness, whether AI needs an inner world and a “body dashboard” to align with human values, simple practices to gain mental room to move this week, and much more…Timestamps: 00:00 Intro03:00 Understanding the Free Energy Principle05:54 Application Beyond Biological Systems11:08 Generative Models and Consciousness18:13 The Dark Room Problem23:06 Generative Models in the Brain36:09 The Brain's Generative Models41:46 The Role of Bioelectricity in Unity49:35 Psychedelics and the Free Energy Principle57:07 Psychedelics: Strengthening and Weakening Beliefs01:07:58 Psychedelics and Serotonin Receptors01:11:49 Compassion in Psychedelic Therapy01:13:30 Exploring Consciousness with Psychedelics01:17:28 DMT Experiences and Entities01:24:12 The Nature of Reality and Consciousness...Neuroscience Products I Swear By (Supports the Channel)Sentia Spirits: https://sentiaspirits.com/mcgloughlin4209355084Manta Sleep Mask: Get the Comfiest Sleep Mask on the Planet (Use Code GIANTSMANTA10 https://bit.ly/4ilzfBL )Brain.FM: Music Entrainment for Focused Deep Work (30 Day Free Trial: https://www.brain.fm/giantsshoulder)Consensus.AI: https://get.consensus.app/we00d2cmjpqeFollow My Neuroscience Podcast - The Giants Shoulder Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=b33232eae67b4126Apple Podcasts - https://podcasts.apple.com/ie/podcast/brief-enquiry-to-the-brain/id1752486249