TWiV 1196: Clinical update with Dr. Daniel Griffin
This Week in Virology
Current Landscape of Respiratory Viruses
This chapter explores the ongoing high levels of RSV and the improving COVID-19 situation, noting a significant drop in national metrics. It discusses the effectiveness of COVID-19 vaccines in preventing severe complications and analyzes the controversial use of unproven treatments. The chapter also highlights the benefits of Paxlovid for high-risk patients while addressing the implications of Long COVID, emphasizing the importance of vaccines in reducing post-infection burdens.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello lament about the downfall of public health from “postponement” of the advisory committee on immunization practices and the FDA VRBPAC influenza strain selection meetings to how the communication pause prevents public notice of NIH study section meetings, and withdrawal of CDC promotions for the ‘flu vaccine’ before discussing the end of Ebola outbreak in Uganda, funding from Saudi Arabia for polio eradication, the continuing and growing measles outbreak in the US including misinformation from the Secretary of HHS, highly pathogenic avian flu and its economic effect, ie the cost of eggs before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions and FDA approval of adjuvanted Novovax COVID vaccine.
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Links for this episode- Phantom ACIP (CDC)
- Postponement of ACIP…..hummmm (STATNews)
- Influenza Strain selection VRBPAC cancelled (Reuters)
- How NIH funded research is impacted by government communication pause (NY Times)
- Can be reviewed but still no money (STATNews)
- Final push to end Ebola in Uganda (WHO Uganda)
- Saudi Arabia sponsors polio eradication effort (GPEI))
- $500 million from Saudi Arabia to immunize 370 million children against polio (CIDRAP)
- Measles 124 in Texas…. (Texas Health and Human Services)
- A Texas child who was not vaccinated has died of measles(AP News)
- The Measles book-(Apple Books)
- Measles vaccination protects against virus infection and other infections (Science)
- Measles deadliest sequelae (MEDPAGE TODAY)
- Measles cases and outbreaks (CDC Measles)
- Unvaccinated Child Dies of Measles in Texas Outbreak(NY Times)
- Texas child is first reported US measles death in a decade as outbreak hits more than 130 (Reuters)
- Trump’s cabinet meeting: Kennedy Shocker “Not unusual”……..seriously! (YouTube)
- First measles death reported in Texas as Kennedy downplays the outbreak (NBC News)
- Measles cliff notes: symptoms timeline (Substackdn)
- Annual state immunization report (Texas Health and Human Services)
- Measles imported into Kentucky…….no tariffs? (Commonwealth of Kentucky)
- Egg shortage affect flu shots? (MEDPAGE TODAY)
- Which Came First, the Chicken Slaughter or the Egg Shortage(Wall Street Journal)
- Avian Influenza in Birds: Causes and How It Spreads (CDC Avian Influenza)
- Agriculture Secretary Brooke Rollins: My Plan to Lower Egg Prices (Wall Street Journal)
- Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Weekly surveillance report: clift notes (CDC FluView)
- RSV: Waste water scan for 11 pathogens (WastewaterSCan)
- Weekly US influenza surveillance report (CDC FluView)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Trump administration yanks CDC flu vaccine campaign(NPR)
- RSV-Network (CDC Respiratory Syncytial virus Infection)
- New wild to mild campaign drives key message to tame flu and reset expectations
- (CDC Influenza)
- Waste water scan for 11 pathogens (WastewaterSCan)
- COVID-19 deaths (CDC)
- COVID-19 national and regional trends (CDC)
- COVID-19 variant tracker (CDC)
- SARS-CoV-2 genomes galore (Nextstrain)
- Effectiveness of the original monovalent messenger RNA Coronavirus Disease 2019 (COVID-19) vaccination series against hospitalization for COVID-19–Associated venous thromboembolism (JID)
- Where to get pemgarda (Pemgarda)
- EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
- Infusion center (Prime Fusions)
- CDC Quarantine guidelines (CDC)
- NIH COVID-19 treatment guidelines (NIH)
- Drug interaction checker (University of Liverpool)
- Demographic variation in US outpatient hydroxychloroquine and ivermectin use during the COVID-19 pandemic (HealthAffairs)
- Paxlovid update (Pfizer)
- Infectious Disease Society guidelines for treatment and management (ID Society)
- Alleviation of COVID-19 symptoms and reduction in healthcare utilization among high-risk patients treated With nirmatrelvir/ritonavir (NMV/R) (CID)
- Molnupiravir safety and efficacy (JMV)
- Convalescent plasma recommendation for immunocompromised (ID Society)
- What to do when sick with a respiratory virus (CDC)
- When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
- Managing healthcare staffing shortages (CDC)
- Steroids, dexamethasone at the right time (OFID)
- Anticoagulation guidelines (hematology.org)
- Daniel Griffin’s evidence based medical practices for long COVID (OFID)
- Long COVID hotline (Columbia : Columbia University Irving Medical Center)
- The answers: Long COVID
- Interventions for Long COVID: A Narrative Review (Journal of General Internal Medicine)
- COVID-19 vaccination and odds of post–COVID-19 condition symptoms in children aged 5 to 17 Years (JAMA Network)
- Novavax COVID-19 vaccine, adjuvanted (FDA)
- Letters read on TWiV 1196
- Dr. Griffin’s COVID treatment summary (pdf)
- Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
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